The house mouse (Mus musculus) is the mouse most often found inside homes and businesses in Illinois. It isn't a native species: it arrived from Europe and lives almost entirely alongside people.
House mice are mostly active at night and nest close to food, using shredded paper, insulation and fabric. They eat grains and seeds but will try almost anything in a kitchen or pantry. A female can have five to ten litters a year, each with around five or six young, and the young can breed at about two months old. That's why a couple of mice in October can become a real infestation by winter.

A mouse can squeeze through a gap about ¼ inch wide, roughly the size of a dime, and it will gnaw a small gap until it fits. Around Chicago, mice move indoors in the fall when temperatures drop, usually from mid-September through November. Common entry points include:
Once inside, they head for quiet, warm spaces: attics, basements, wall voids, behind appliances and inside kitchen cabinets.
Seeing a live or dead mouse is the obvious sign, but most people notice something else first:
A young rat can look like a large mouse, so check the details:
| House mouse | Norway rat | |
|---|---|---|
| Body length | 2½–3½ in | 7–10 in |
| Head and feet | Small in proportion to the body | Large and heavy |
| Droppings | ⅛–¼ in, pointed | ½–¾ in, blunt |
| Smallest gap | ¼ in (a dime) | ½ in (a quarter) |
Learn more on our Norway rat page.
Illinois also has two native mice that come indoors in late fall: the deer mouse and the white-footed mouse. They're common in homes near forest preserves, parks and open fields. They're easy to tell apart from house mice:
The difference matters for your health. Deer mice and white-footed mice are the main carriers of hantavirus in the US, and white-footed mice are also hosts in the life cycle of the ticks that spread Lyme disease. If you think you have deer mice, take extra care when cleaning up (see below).
House mice contaminate food and surfaces with their droppings, urine and saliva. According to the CDC, the house mouse is the main carrier of lymphocytic choriomeningitis virus (LCMV), which can be serious for pregnant women and people with weakened immune systems. Mice can also spread salmonella, which causes food poisoning.
They also cause damage. Mice gnaw constantly to keep their teeth worn down, and they'll chew through wood, plastic, insulation and electrical wiring. Chewed wiring in walls and attics is a fire risk.
Don't sweep or vacuum droppings or nests, because that sends dust into the air. Instead:
For heavy contamination in attics, crawl spaces or garages, ask a professional.

A mouse problem is solved in two parts: removing the mice that are inside, and stopping new ones getting in.
If mice keep coming back, or you'd rather not deal with them yourself, our IDPH-licensed technicians can inspect your home, find every entry point, set up a treatment plan and seal the gaps.
Need help? See our mouse control service or book an inspection online.